Gilberto De Nucci Selected Research

4-(((4-carboxybutyl) (2- (5-fluoro-2-((4'-(trifluoromethyl) biphenyl-4-yl)methoxy)phenyl)ethyl) amino)methyl)benzoic acid

12/2016	The soluble guanylyl cyclase activator BAY 60-2770 inhibits murine allergic airways inflammation and human eosinophil chemotaxis.
11/2014	Prolonged therapy with the soluble guanylyl cyclase activator BAY 60-2770 restores the erectile function in obese mice.
2/2014	The soluble guanylyl cyclase activator BAY 60-2770 ameliorates overactive bladder in obese mice.
1/2012	Activation of haem-oxidized soluble guanylyl cyclase with BAY 60-2770 in human platelets lead to overstimulation of the cyclic GMP signaling pathway.

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Gilberto De Nucci Research Topics

Disease

8	Erectile Dysfunction 09/2019 - 05/2008
5	Overactive Urinary Bladder (Overactive Bladder) 09/2019 - 01/2012
4	Inflammation (Inflammations) 12/2016 - 01/2001
4	Cardiovascular Diseases (Cardiovascular Disease) 02/2014 - 05/2006
4	Hypertension (High Blood Pressure) 04/2007 - 01/2001
3	Pain (Aches) 01/2019 - 05/2003
2	Premature Ejaculation 01/2022 - 08/2012
2	Prostatic Hyperplasia (Benign Prostatic Hyperplasia) 06/2019 - 03/2015
2	Diarrhea 04/2019 - 03/2013
2	Neoplasms (Cancer) 10/2018 - 02/2005
2	Vascular Diseases (Vascular Disease) 11/2014 - 01/2012
2	Obesity 02/2014 - 05/2013
2	Insulin Resistance 05/2013 - 01/2012
2	Cognitive Dysfunction 01/2008 - 12/2005
2	Bradycardia 04/2007 - 10/2004
2	Pulmonary Hypertension 01/2007 - 01/2004
2	Pneumonia (Pneumonitis) 11/2006 - 11/2005
2	Fibrosis (Cirrhosis) 03/2006 - 02/2002
2	Hypertrophy 03/2006 - 02/2002
1	Hemorrhage 06/2021
1	Lung Injury 01/2021
1	Thrombosis (Thrombus) 01/2021
1	COVID-19 01/2021
1	Myalgia 09/2020
1	Neural Tube Defects (Exencephaly) 06/2019
1	Spinal Cord Injuries (Spinal Cord Injury) 01/2019
1	Hypoxia (Hypoxemia) 01/2019
1	Weight Loss (Weight Reduction) 01/2019
1	Stroke (Strokes) 01/2019
1	Amyotrophic Lateral Sclerosis (Lou Gehrig's Disease) 01/2019
1	Tinea Pedis (Athlete's Foot) 01/2018
1	Paraganglioma (Paragangliomas) 01/2018
1	Asthma (Bronchial Asthma) 12/2016
1	Molluscum Contagiosum 05/2016
1	Cystitis 01/2016
1	Tinea Versicolor (Pityriasis Versicolor) 01/2015

Drug/Important Bio-Agent (IBA)

7	Nitric Oxide (Nitrogen Monoxide)FDA Link 06/2019 - 01/2001
7	Soluble Guanylyl CyclaseIBA 12/2016 - 01/2007
5	Nitric Oxide Synthase (NO Synthase)IBA 02/2009 - 02/2002
4	4-(((4-carboxybutyl) (2- (5-fluoro-2-((4'-(trifluoromethyl) biphenyl-4-yl)methoxy)phenyl)ethyl) amino)methyl)benzoic acidIBA 12/2016 - 01/2012
4	NG-Nitroarginine Methyl Ester (L-NAME)IBA 02/2009 - 02/2002
3	Heparin (Liquaemin)FDA LinkGeneric 01/2021 - 01/2004
3	Phosphodiesterase 5 InhibitorsIBA 10/2015 - 05/2008
3	Proteins (Proteins, Gene)FDA Link 01/2012 - 01/2007
2	Biological ProductsIBA 01/2021 - 03/2013
2	mirabegronIBA 09/2019 - 03/2015
2	Protein Isoforms (Isoforms)IBA 01/2019 - 05/2002
2	Hydrochlorothiazide (Esidrix)FDA LinkGeneric 01/2019 - 06/2016
2	Ketoconazole (Nizoral)FDA LinkGeneric 01/2018 - 01/2015
2	1- (2- (2,4- dichlorophenyl)- 2- (4- (trifluoromethyl)benzyloxy)ethyl)- 1H- imidazoleIBA 01/2018 - 01/2015
2	Adrenergic Receptors (Adrenergic Receptor)IBA 03/2015 - 02/2002
2	Heme (Haem)IBA 11/2014 - 01/2012
2	Insulin (Novolin)FDA Link 05/2013 - 01/2012
2	Type 5 Cyclic Nucleotide PhosphodiesterasesIBA 12/2012 - 05/2008
2	Enterotoxins (Enterotoxin)IBA 09/2008 - 11/2006
2	Protamines (Protamine Sulfate)FDA Link 01/2007 - 01/2004
2	3- (4- Amino- 5- cyclopropylpyrimidine- 2- yl)- 1- (2- fluorobenzyl)- 1H- pyrazolo(3,4- b)pyridineIBA 01/2007 - 03/2006
2	Propranolol (Inderal)FDA LinkGeneric 05/2006 - 02/2002
1	Therapeutic UsesIBA 01/2022
1	Tricyclic Antidepressive Agents (Tricyclic Antidepressants)IBA 01/2022
1	Progesterone FDA LinkGeneric 06/2021
1	Estradiol (Delestrogen)FDA LinkGeneric 06/2021
1	AnticoagulantsIBA 01/2021
1	Simvastatin (Zocor)FDA LinkGeneric 09/2020
1	Piracetam (Nootropil)IBA 09/2020
1	Carnitine (L-Carnitine)FDA LinkGeneric 09/2020
1	Tadalafil (Cialis)FDA Link 06/2019
1	Folic Acid (Vitamin M)FDA LinkGeneric 06/2019
1	Guanosine Monophosphate (5' Guanylic Acid)IBA 06/2019
1	Cyclic NucleotidesIBA 04/2019
1	7- nitro- 5- phenyl- 1- (pyrrolidin- 1- ylmethyl)- 1H- benzo(e)(1,4)diazepin- 2(3H)- oneIBA 01/2019
1	Riluzole FDA LinkGeneric 01/2019
1	benzothiazoleIBA 01/2019
1	Neuroprotective AgentsIBA 01/2019
1	Antihypertensive Agents (Antihypertensives)IBA 01/2019
1	Anticonvulsants (Antiepileptic Drugs)IBA 01/2019
1	Sodium Chloride Symporter Inhibitors (Diuretics, Thiazide)IBA 01/2019
1	Amiloride (Midamor)FDA LinkGeneric 01/2019
1	Pharmaceutical PreparationsIBA 01/2019
1	Amoxicillin (Wymox)FDA LinkGeneric 01/2019
1	Thymidine PhosphorylaseIBA 10/2018
1	Capecitabine (Xeloda)FDA Link 10/2018
1	Fluorouracil (Carac)FDA LinkGeneric 10/2018
1	ProdrugsIBA 10/2018
1	S100 Proteins (S 100 Protein)IBA 01/2018
1	Tyrosine 3-Monooxygenase (Tyrosine Hydroxylase)IBA 01/2018
1	DiureticsIBA 06/2016
1	HydrogelsIBA 05/2016
1	Prilocaine Drug Combination Lidocaine FDA LinkGeneric 05/2016
1	Cyclophosphamide (Cytoxan)FDA LinkGeneric 01/2016
1	BAY 58-2667IBA 01/2016
1	Analgesics (Analgesic Drugs)IBA 06/2015
1	Oxidoreductases (Dehydrogenase)IBA 03/2015
1	Phosphoric Diester Hydrolases (Phosphodiesterases)IBA 03/2015
1	imidazoleIBA 01/2015

Therapy/Procedure

2	Intravenous Administration 01/2019 - 01/2004
1	Artificial Respiration (Mechanical Ventilation) 01/2021
1	Lasers (Laser) 01/2019
1	Cryotherapy (Therapy, Cold) 05/2016
1	Therapeutics 03/2015